ABSTRACT
Background: Reflux disease is a common gastrointestinal problem. The association between reflux disease and gastritis pattern is controversial
Aim: To determine the association between reflux disease and gastritis pattern in patients with Helicobacter pylori [H. pylori] infection
Methods: 470 patients with dyspepsia and reflux disease were enrolled in this study. The inclusion criteria were willing to participate in the study, age over 40 years, and having the criteria of ROME III for at least 3 months. Patients with history of H. pylori eradication therapy during the 3 months before the study, a history of gastric surgery, and gastric cancer were excluded. All of the participants underwent upper endoscopy and two biopsy samples were taken from antrum, body, and fundal areas
Results: H. pylori infection rate was 367 [78.1%] with mean age of 59.8 +/- 11.4 years. Of them 131 patients [35.7%] were male. Reflux disease was detected in 273 [74.4%] patients. 216 [58.9%] and 102 [27.8%] patients had non-erosive reflux disease [NERD] and gastroesophageal reflux disease [GERD], respectively. Corpus predominant and antral predominant gastritis were seen in 72 [19.6%] and 129 [35.2%] patients, respectively. Antral gastritis was significantly associated with GERD [p<0.01]. In regression analysis, antral predominant gastritis had a significant association with GERD [OR=1.92; 95%CI: 1.22-3.12]. The same result was observed in mild to moderate antral and greater curvature gastritis [OR= 1.26; 95%CI: 0.25-6.40 and OR= 3.0; 95%CI: 0.63-14.17, respectively]
Conclusion: According to these finding, we could suggest that the pattern of gastritis could be associated with reflux disease and GERD
ABSTRACT
Obstructive lung disease is a growing health problem, especially in developed countries. This study aimed to compare Impulse Osillometry System [IOS] and Spirometry for evaluation of Chronic Obstructive Pulmonary Disease and asthma. The study groups contained 87 healthy people, 87 asthmatic patients and 56 COPD patients. Spirometry [FVC, FEV1, FEV1/FVC] and IOS [R5, R20, X5] measurements were performed for all the healthy subjects and patients. The results of IOS were compared with spirometric results. Significant differences were detected among the 3 groups [control, COPD and asthma] in terms of all the spirometric parameters [FVC, FEV1, FEV1/FVC] and some parameters of IOS [R5,R20,X5] measurements [p<0.05]. Among COPD patients, sensitivity for X5 [the best value of IOS measurements in the COPD group] was 76%. Also, in asthmatic patients, sensitivity for R20 [the best value of IOS measurements in the asthma group] was 77%. We found a correlation between R5, R20 and X5 with FEV1 in asthmatic patients, but only R5 had this correlation with FEV1 in COPD patients. We concluded that IOS can be an alternative for spirometry in the diagnosis of obstructive lung disease in patients with minimal cooperation. R5 can represent COPD severity